METHOD

PROBLEM TO BE SOLVED: To provide mixed metal compounds which have a phosphate-binding capacity, for the prevention or treatment of any one of hyperphosphataemia, renal insufficiency, hypoparathyroidism, pseudohypoparathyroidism, acute untreated acromegaly, chronic kidney disease and over medication of phosphate salts.SOLUTION: This invention relates to a method of producing a mixed metal compound comprising at least Mgand at least Fehaving an aluminium content of less than 10,000 ppm, and having an average crystal size of less than 20 nm (200 ), the method comprising the steps of: (a) combining a Mgsalt and an Fesalt with NaCOand NaOH to produce a slurry, wherein the pH of the slurry is maintained at from 9.5 to 11; (b) subjecting the slurry to mixing under conditions providing a power per unit volume of 0.03 to 1.6 kW/m; (c) separating the mixed metal compound from the slurry, to obtain a crude product having a dry solid content of at least 10 wt%; and (d) drying the crude product either by heating the crude product (i) to a temperature of no greater than 150°C. 【課題】高リン酸塩血症、腎不全、副甲状腺機能低下、偽副甲状腺機能低下、急性未治療末端肥大症、慢性腎臓病、およびリン酸塩の過剰服用のいずれか１つの予防または治療の為、リン酸結合能力を有する混合金属酸化物およびその製造方法を提供。【解決手段】少なくともＭｇ２＋および少なくともＦｅ３＋を含み、１００００ｐｐｍ未満のアルミニウム含有量を有し、平均結晶サイズ２０ｎｍ（２００ ）未満の混合金属化合物を生成する方法。（ａ）Ｍｇ２＋塩およびＦｅ３＋塩をＮａ２ＣＯ３およびＮａＯＨと合わせて、スラリーを生成し、ｐＨ９．５〜１１に維持すステップと、（ｂ）０．０３〜１．６ｋＷ／ｍ３の単位体積当たりの動力条件下で、スラリーを混合するステップと、（ｃ）混合金属化合物をスラリーから分離、少なくとも１０重量％の乾燥固形分量の粗生成物を得、（ｄ）（ｉ）粗生成物を、１５０℃以下の温度で乾燥させるステップと、を含む、方法。【選択図】図１