METHOD OF PRODUCING SYMMETRIC 4,6-BIS(ARYLOXY) PYRIMIDINE COMPOUND
PROBLEM TO BE SOLVED: To provide a method whereby it is possible to produce symmetric 4,6-bis[4-fluoro-3-(trifluoromethyl) phenoxy] pyrimidine in an industrially advantageous manner and with high purity and high yields.SOLUTION: In a reaction of 4,6-dichloro pyrimidine with 4-fluoro-3-(trifluorometh...
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| Format: | Patent |
| Sprache: | eng ; jpn |
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| Zusammenfassung: | PROBLEM TO BE SOLVED: To provide a method whereby it is possible to produce symmetric 4,6-bis[4-fluoro-3-(trifluoromethyl) phenoxy] pyrimidine in an industrially advantageous manner and with high purity and high yields.SOLUTION: In a reaction of 4,6-dichloro pyrimidine with 4-fluoro-3-(trifluoromethyl) phenol, as a catalyst, 1,4-diazabicyclo [2.2.2] octane compounds, quinuclidine compounds or N-methyl pyrrolidine compounds, or salts thereof are used.
【課題】工業的に非常に有利に生産でき、かつ高純度、高収率で、対象性４,６−ビス[４−フルオロ−３−（トリフルオロメチル）フェノキシ]ピリミジンを製造できる方法を提供する。【解決手段】４,６−ジクロロピリミジンと、４−フルオロ−３−（トリフルオロメチル）フェノールとを反応させる際に、触媒として、１，４−ジアザビシクロ[２.２.２]オクタン化合物、キヌクリジン化合物又はＮ-メチルピロリジン化合物、又はその塩が使用される。【選択図】なし |
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