AROMATIC-SUBSTITUTED XANTHENE DYES

PROBLEM TO BE SOLVED: To provide an aromatic-substituted xanthene compound that is useful as a fluorescent dye for use in the independent detection of multiple spatially overlapping analytes in a mixture, e.g, single-tube multiplex DNA probe assays, immuno assays, multicolor DNA sequencing methods,...

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Bibliographische Detailangaben
Hauptverfasser:	BENSON SCOTT CONRAD, THEISEN PETER DAVID, MENCHEN STEVEN MICHAEL, UPADHYA KRISHNA GAJANAN, HAUSER JOAN DALE
Format:	Patent
Sprache:	eng ; jpn
Schlagworte:	ADHESIVES BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS OR TEST PAPERS THEREFOR COMPOSITIONS THEREOF CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES CULTURE MEDIA DERIVATIVES THEREOF DYES ENZYMOLOGY HETEROCYCLIC COMPOUNDS INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES LAKES MATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FORELSEWHERE MEASURING MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MISCELLANEOUS APPLICATIONS OF MATERIALS MISCELLANEOUS COMPOSITIONS MORDANTS MUTATION OR GENETIC ENGINEERING NATURAL RESINS NUCLEIC ACIDS NUCLEOSIDES NUCLEOTIDES ORGANIC CHEMISTRY ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES PAINTS PHYSICS POLISHES PROCESSES OF PREPARING SUCH COMPOSITIONS PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS SUGARS TESTING VINEGAR WINE
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Beschreibung
Zusammenfassung:	PROBLEM TO BE SOLVED: To provide an aromatic-substituted xanthene compound that is useful as a fluorescent dye for use in the independent detection of multiple spatially overlapping analytes in a mixture, e.g, single-tube multiplex DNA probe assays, immuno assays, multicolor DNA sequencing methods, and the like.SOLUTION: The present invention provides a composition of the formula (Yand Yseparately selected from the group consisting of hydroxyl, oxygen, imminium, linking group and amine, or Ytogether with Ris cyclic amine, or Ytogether with Ris cyclic imine; R, R, R, and Rseparately selected from the group consisting of hydrogen, fluorine, chlorine, lower alkyl, lower alkene, lower alkyne, sulfonate, sulfone, amino, imminium, amido, nitrile, lower alkoxy, phenyl, and linking group). 【課題】混合物中の複数の空間的に重複した分析物の独立した検出、例えば、単一管の多重ＤＮＡプローブアッセイ、イムノアッセイ、多色ＤＮＡ配列決定法などで使用する蛍光色素として有用な芳香族置換キサンテン化合物の提供。【解決手段】下式の化合物。（Ｙ１およびＹ２は、別々に、ヒドロキシル、酸素、イミニウム、連結基およびアミンからなる群から選択されるか、またはＹ１は、Ｒ２と一緒になって、環状イミンであるか、またはＹ２は、Ｒ３と一緒になって、環状アミンである；Ｒ２、Ｒ３、Ｒ５およびＲ７は、別々に、水素、フッ素、塩素、低級アルキル、低級アルケン、低級アルキン、スルホネート、スルホン、アミノ、イミニウム、アミド、ニトリル、低級アルコキシ、フェニルおよび連結基からなる群から選択される。）【選択図】なし