MODIFIED FGF-21 POLYPEPTIDES

PROBLEM TO BE SOLVED: To provide fibroblast growth factor (FGF)-21 polypeptides comprising one or more non-naturally encoded amino acids.SOLUTION: An FGF-21 polypeptide comprises one or more non-naturally encoded amino acids, comprises one or more post-translational modifications, and is linked to a...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Hauptverfasser:	ROBERTO MARIANI, THOMAS P CUJEC, VADIM KRAYNOV, HO LILLIAN, NICK KNUDESEN, ANNA-MARIA A HAYS PUTNAM, WILLIAM M KEEFE, JASON PINKSTAFF
Format:	Patent
Sprache:	eng ; jpn
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE
Online-Zugang:	Volltext bestellen
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	PROBLEM TO BE SOLVED: To provide fibroblast growth factor (FGF)-21 polypeptides comprising one or more non-naturally encoded amino acids.SOLUTION: An FGF-21 polypeptide comprises one or more non-naturally encoded amino acids, comprises one or more post-translational modifications, and is linked to a linker, polymer, or biologically active molecule. Further, the FGF-21 polypeptide is linked to a bifunctional polymer, bifunctional linker, or at least one additional FGF-21 polypeptide. In addition, in the FGF-21 polypeptide, the bifunctional polymer or bifunctional linker is linked to a second polypeptide. 【課題】非天然にコードされるアミノ酸を１つ以上含んでいる線維芽細胞成長因子（ＦＧＦ）−２１ポリペプチドの提供。【解決手段】非天然にコードされるアミノ酸を１つ以上含んでいる、ＦＧＦ−２１ポリペプチドであり、翻訳後修飾を１つ以上含み、リンカー、ポリマー又は生物学的に活性な分子と連結されるＦＧＦ−２１ポリペプチド。更に、二官能性ポリマー、二官能性リンカー、又は少なくとも１つのさらなるＦＧＦ−２１ポリペプチドと連結されるＦＧＦ−２１ポリペプチド。また、二官能性ポリマー又は二官能性リンカーが第２のポリペプチドと連結されているＦＧＦ−２１ポリペプチド。【選択図】なし