SINGLE-DOMAIN ANTIGEN-BINDING PROTEIN THAT BINDS MAMMALIAN IgG

PROBLEM TO BE SOLVED: To provide an antigen-binding protein capable of binding to mammalian IgG.SOLUTION: The antigen-binding protein of the invention has a framework region preferably corresponding to that of an antibody naturally lacking the light chain as found in camelids. Further, the invention...

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Hauptverfasser:	WILHELMUS JOSEPHUS JOHANNA HERMANS, SANDRA BEZEMER, YVONNE MATHALIE MIJNSBERGEN
Format:	Patent
Sprache:	eng ; jpn
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE HUMAN NECESSITIES HYGIENE INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PHYSICS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS TESTING VINEGAR WINE
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Beschreibung
Zusammenfassung:	PROBLEM TO BE SOLVED: To provide an antigen-binding protein capable of binding to mammalian IgG.SOLUTION: The antigen-binding protein of the invention has a framework region preferably corresponding to that of an antibody naturally lacking the light chain as found in camelids. Further, the invention relates to a nucleic acid encoding such an antigen-binding protein, an immunoabsorbent including such a protein, and use of such an immunoabsorbent for purification of mammalian IgG antibodies, and for therapeutic apheresis. 【課題】哺乳動物ＩｇＧと結合できる抗原結合タンパク質の提供。【解決手段】抗原結合タンパク質のフレームワーク領域は、ラクダ科動物において見ることができるような、天然に軽鎖を欠く抗体の領域に対応することが好ましい。さらに、このような抗原結合タンパク質をコードする核酸、このようなタンパク質を含む免疫吸着物質、哺乳動物ＩｇＧ抗体の精製のため、及び治療的アフェレーシスのためのこのような免疫吸着物質の使用に関する。【選択図】なし