PROPOLIS- AND QUERCETIN-CONTAINING COMPOSITION WITH ENHANCED ANTI-INFLAMMATORY ACTIVITY

PROBLEM TO BE SOLVED: To provide an excellent anti-inflammatory drug composition having better anti-inflammatory activity than propolis, a TNF-α gene expression inhibitor for a macrophage comprising the anti-inflammatory drug composition, and a food product, a pharmaceutical and a quasi drug compris...

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Bibliographische Detailangaben
Hauptverfasser:	MATSUI TAKEKI, YAMADA YASUMASA, MATSUKAWA TAIJI, DOI SATOSHI, KUZUMI AKINOBU, HAZA YOSHIMI, YAMADA ICHIRO
Format:	Patent
Sprache:	eng ; jpn
Schlagworte:	FOODS OR FOODSTUFFS FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BYSUBCLASSES A23B - A23J HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OFNUTRITIVE QUALITIES, PHYSICAL TREATMENT THEIR TREATMENT, NOT COVERED BY OTHER CLASSES
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Zusammenfassung:	PROBLEM TO BE SOLVED: To provide an excellent anti-inflammatory drug composition having better anti-inflammatory activity than propolis, a TNF-α gene expression inhibitor for a macrophage comprising the anti-inflammatory drug composition, and a food product, a pharmaceutical and a quasi drug comprising the anti-inflammatory drug composition.SOLUTION: An anti-inflammatory drug composition comprises the propolis and quercetin heat-treated substance obtained by applying heat treatment to propolis and quercetin in the presence of metal salt. There are also provided a TNF-α gene expression inhibitor for a macrophage comprising the anti-inflammatory drug composition, and a food product, a pharmaceutical and a quasi drug comprising the anti-inflammatory drug composition. 【課題】プロポリスよりも優れた抗炎症作用を有する優れた抗炎症剤組成物、該抗炎症剤組成物を含むマクロファージのＴＮＦ−α遺伝子発現抑制剤、並びに食品、医薬品および医薬部外品を提供すること。【解決手段】プロポリスとケルセチンとを金属塩存在下で加熱処理して得られるプロポリス・ケルセチン加熱処理物を含むことを特徴とする抗炎症剤組成物、該抗炎症剤組成物を含有することを特徴とするマクロファージのＴＮＦ−α遺伝子発現抑制剤、並びに食品、医薬品及び医薬部外品。【選択図】なし