COMPOSITIONS AND METHODS FOR MINIMALLY INVASIVE SYSTEMIC DELIVERY OF PROTEINS INCLUDING TGF- -SUPERFAMILY MEMBERS

PROBLEM TO BE SOLVED: To provide compositions and methods for minimally invasive systemic delivery of proteins including TGF- -superfamily members.SOLUTION: The invention is directed to methods and compositions for systemic delivery of minimally soluble bioactive agents such as, but not limited to,...

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Hauptverfasser:	ALLEN RICHARD PIERCE, DENIS SCHRIER, MARY ELIZABETH PECQUET GOAD
Format:	Patent
Sprache:	eng
Schlagworte:	HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	PROBLEM TO BE SOLVED: To provide compositions and methods for minimally invasive systemic delivery of proteins including TGF- -superfamily members.SOLUTION: The invention is directed to methods and compositions for systemic delivery of minimally soluble bioactive agents such as, but not limited to, TGF- -superfamily proteins. According to the invention, an exemplary bioactive agent is BMP-7. The invention also provides minimally invasive systemic treatment of skeletal disorders such as osteoporosis. The invention also provides minimally invasive systemic treatment of damaged or diseased non-calcified tissues and organs such as kidneys. Practice of the invention eliminates adverse side effects at the sites of intravenous administration of the bioactive agent.