SOLID FORM OF THE MAGNESIUM SALT OF (S)-OMEPRAZOLE AND METHOD FOR MANUFACTURING THE SAME

PROBLEM TO BE SOLVED: To provide a novel solid form of the magnesium salt of (S)-omeprazole and a method for manufacturing the same.SOLUTION: The provided method for manufacturing a novel solid form comprises: a) a step of crystallizing an S-omeprazole magnesium salt from an S-omeprazole magnesium s...

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Hauptverfasser:	RAMON BERENGUER MAIMO, GUILLEN YOLANDA GASANZ, JORGE MEDRANO RUPEREZ, LAURA COPPI
Format:	Patent
Sprache:	eng
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	PROBLEM TO BE SOLVED: To provide a novel solid form of the magnesium salt of (S)-omeprazole and a method for manufacturing the same.SOLUTION: The provided method for manufacturing a novel solid form comprises: a) a step of crystallizing an S-omeprazole magnesium salt from an S-omeprazole magnesium salt solution within a solvent system including a methanol/water mixture including at least 0.01 mL of water with respect to 1 g of an S-omeprazole magnesium salt starting material; b) a step of separating the S-omeprazole magnesium salt emerging at the previous step; and c) a step of separating a free organic solvent from the obtained S-omeprazole magnesium salt.