ADMINISTRATION OF THE REG1 ANTICOAGULATION SYSTEM

PROBLEM TO BE SOLVED: To provide an improved method of administration of an aptamer and antidote system to regulate blood coagulation in a host.SOLUTION: The method is provided based on weight-adjusted or body mass index-adjusted dosing of the components of the system to provide a desired pharmacody...

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Bibliographische Detailangaben
Hauptverfasser:	CHRISTOPHER P RUSCONI, ROSS M TONKENS
Format:	Patent
Sprache:	eng
Schlagworte:	HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	PROBLEM TO BE SOLVED: To provide an improved method of administration of an aptamer and antidote system to regulate blood coagulation in a host.SOLUTION: The method is provided based on weight-adjusted or body mass index-adjusted dosing of the components of the system to provide a desired pharmacodynamic response. As a specific procedure, the invention provides a method of administration of an aptamer comprising: a. measuring the body mass index (BMI) of a host; b. identifying a desired pharmacodynamic response; and c. administering to the host a dose of an aptamer to achieve a desired pharmacodynamic response based on a comparison of the dose per BMI to the pharmacodynamic response.