INTERMEDIATES AND METHODS FOR MAKING ZEARALENONE MACROLIDE ANALOGS

PROBLEM TO BE SOLVED: To provide intermediates and preparation methods for making zearalenone macrolide analogs.SOLUTION: The present invention provides compounds of the formula (IV), and intermediates and preparation methods of the compounds. [Rand Rare H or the like; Rand Rare H, or a 5-6 membered...

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Hauptverfasser: ROCH BOIVIN, NIU XIANG, LEE JIN, PAMELA MCGUINNESS, KEVIN (KUO-MING) WU, MATTHEW J SCHNADERBECK, SILVIO A CAMPAGNA, XIAOJIE (JEFF) ZHU, DU HONG, THOMAS HORSTMANN, FRANCIS G FANG, CHARLES-ANDRE LEMELIN
Format: Patent
Sprache:eng
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Zusammenfassung:PROBLEM TO BE SOLVED: To provide intermediates and preparation methods for making zearalenone macrolide analogs.SOLUTION: The present invention provides compounds of the formula (IV), and intermediates and preparation methods of the compounds. [Rand Rare H or the like; Rand Rare H, or a 5-6 membered unconjugated carbocyclic ring including the carbon atoms to which they are attached; Ris H, -ORa (Ra is H, a base stable oxygen protecting group, or the like) or the like; Ris H, -ORg (Rg is H or a base stable oxygen protecting group) or the like; Ris H or the like; Ris H or -ORc (Rc is H or a base stable oxygen protecting group); and Rand Rare H, a 5 membered heterocyclyldiyl including Rand R, or the like.]