COMPOSITION FOR MUCOSA
PROBLEM TO BE SOLVED: To provide a composition for mucosa where stability of the lipid-soluble active ingredient is maintained and also the appearance of the composition for mucosa is uniformed, adsorption of a lipid-soluble active ingredient into a mucosa such as cornea, conjunctiva, nasal mucous a...
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Zusammenfassung: | PROBLEM TO BE SOLVED: To provide a composition for mucosa where stability of the lipid-soluble active ingredient is maintained and also the appearance of the composition for mucosa is uniformed, adsorption of a lipid-soluble active ingredient into a mucosa such as cornea, conjunctiva, nasal mucous and oral cavity throat is enhanced and the effect is more exerted, as the lipid-soluble active ingredient is compounded with the composition for mucosa.SOLUTION: A composition for mucosa contains (A) 0.001 to 1.0 W/V% of a lipid-soluble active ingredient and (B) a nonionic surfactant selected from polyoxyethylene polyoxypropylene copolymers where the mass ratio presented by (A):(B) is 1:0.4 to 24.0; and comprises lipid-soluble active ingredient-containing nanoemulsion particles which are obtained by adding an oil phase comprising the components (A) and (B) to an aqueous phase at 75 to 90°C followed by stirring and have the components (A) and (B) as constitutional components. |
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