COMPOSITION COMPRISING NANOEMULSION PARTICLE AND PRODUCTION METHOD THEREOF

PROBLEM TO BE SOLVED: To provide a composition comprising lipid-soluble active ingredient-containing nanoemulsion particles where the appearance of the composition is transparent, dryness (dry eye) is improved and stimulation is suppressed, as a lipid-soluble active ingredient such as vitamin A is c...

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Bibliographische Detailangaben
Hauptverfasser: MIYAKE MIYUKI, ARITA ATSUYA, SASAKI KANA, KIKUCHI MAIKO, OKUMURA TAKASHI, SASAKI HIDENORI, ISHII REIKO, HATTORI MANABU
Format: Patent
Sprache:eng
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Zusammenfassung:PROBLEM TO BE SOLVED: To provide a composition comprising lipid-soluble active ingredient-containing nanoemulsion particles where the appearance of the composition is transparent, dryness (dry eye) is improved and stimulation is suppressed, as a lipid-soluble active ingredient such as vitamin A is compounded with the composition.SOLUTION: A composition contains (A) 0.0005 to 1.0 W/V% of a lipid-soluble active ingredient, (B-I) 0.5 W/V% or less of polyoxyethylene cured castor oil and/or polyoxyethylene sorbitan fatty acid ester where the mass ratio presented by (A):(B-I) is 1:0.4 to 10, and (C) a water-soluble polymer compound; and comprises nanoemulsion particles which are obtained by adding an oil phase comprising the components (A) and (B-I) to an aqueous phase at 75 to 90°C followed by stirring and contains the components (A) and (B-I) as constitutional components.