CROSS-LINKED COLLAGEN AND USE OF THE SAME

PROBLEM TO BE SOLVED: To provide a cross-linked collagen implant having improved volume stability ("sustention"), useful for correction and orthopedic surgery of a deep layer of skin.SOLUTION: The cross-linked collagen implant material includes a cross-linked collagen filler composition wh...

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Bibliographische Detailangaben
Hauptverfasser:	JACQUELINE A SCHROEDER, KENNETH C OLSON, GREGORY S DAPPER
Format:	Patent
Sprache:	eng
Schlagworte:	CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, ORSURGICAL ARTICLES DISINFECTION, STERILISATION, OR DEODORISATION OF AIR HUMAN NECESSITIES HYGIENE MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICALARTICLES MEDICAL OR VETERINARY SCIENCE METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS INGENERAL
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Beschreibung
Zusammenfassung:	PROBLEM TO BE SOLVED: To provide a cross-linked collagen implant having improved volume stability ("sustention"), useful for correction and orthopedic surgery of a deep layer of skin.SOLUTION: The cross-linked collagen implant material includes a cross-linked collagen filler composition which is manufactured by a method including the steps of: incubating a collagen selected from the group consisting of I-type collagen, II-type collagen, III-type collagen, IV-type collagen, V-type collagen, telo-containing collagen, atelocollagen, derivatized collagen, and a combination thereof, in a suspension or solution having a pH in the range of pH 2 to 5 or pH 9 to 12, so as to form into a micro or non-fibril collagen; treating the collagen with a cross-linking agent selected from the group consisting of carbodiimide, polyaldehyde, polysulfone, activated PEG, epoxide, imidazole and diisocyanate, in particular with glutaric aldehyde, at pH 2 to 5 or pH 9 to 12; and isolating the cross-linked collagen.