BMP MUTANT HAVING LOW SENSITIVITY TO NOGGIN

PROBLEM TO BE SOLVED: To provide a BMP mutant having low sensitivity to noggin.SOLUTION: The present invention provides modified, highly potent bone morphogenetic proteins. In particular, the present invention relates to an observation that BMP-6 and BMP-9 are less susceptible to inhibition by Noggi...

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Bibliographische Detailangaben
Hauptverfasser:	MOULAY HICHAM ALAOUI-ISMAILI, KENING SONG
Format:	Patent
Sprache:	eng
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	PROBLEM TO BE SOLVED: To provide a BMP mutant having low sensitivity to noggin.SOLUTION: The present invention provides modified, highly potent bone morphogenetic proteins. In particular, the present invention relates to an observation that BMP-6 and BMP-9 are less susceptible to inhibition by Noggin than the other members of the BMP subfamily of proteins. The present invention features a chimeric bone morphogenetic protein having a middle portion of BMP-6 or BMP-9 replacing the corresponding portion of a BMP subfamily protein other than BMP-6 and BMP-9 to cause resistance to inhibition by Noggin or other Noggin-like antagonists. Other embodiments of modified BMPs, compositions and methods of use are also included.