ISOXAZOLE DERIVATIVES AND THEIR USE AS METABOTROPIC GLUTAMATE RECEPTOR POTENTIATORS

ISOXAZOLE DERIVATIVES AND THEIR USE AS METABOTROPIC GLUTAMATE RECEPTOR POTENTIATORS

PROBLEM TO BE SOLVED: To provide isoxazole derivatives that function as potentiators of glutamate receptors, methods for producing the same, pharmaceutical compositions containing the same, and use of the same in therapy.SOLUTION: Compounds represented by the formula, pharmaceutically acceptable sal...

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Bibliographische Detailangaben
Hauptverfasser: JOSEPH CACCIOLA, SCOTT THRONER, JAMES EMPFIELD, ANGELA M HUNTER, FOLMER JAMES
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:PROBLEM TO BE SOLVED: To provide isoxazole derivatives that function as potentiators of glutamate receptors, methods for producing the same, pharmaceutical compositions containing the same, and use of the same in therapy.SOLUTION: Compounds represented by the formula, pharmaceutically acceptable salts thereof, methods of producing the same, pharmaceutical compositions containing the same, and methods for using the same. (For example, Ris methyl, trifluoromethyl or cyclopropyl; Rand Rin combination with the nitrogen to which they are attached form a cyclic moiety such as morpholino, pyrrolidinyl or piperazinyl.