NOVEL SULFATED OLIGOSACCHARIDE DERIVATIVES

PROBLEM TO BE SOLVED: To provide: novel compounds that have utility as inhibitors of heparan sulfate-binding proteins; compositions comprising the compounds; and use of the compounds and the compositions comprising the compounds for the antiangiogenic, antimetastatic, anti-inflammatory, antimicrobia...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser:	TOMISLAV KAROLI, KENNETH DAVID JOHNSTONE, LIU LIGONG, PARL NEWTON HANDLEY, EDWARD TIMOTHY HAMMOND, VITO FERRO, NORBERT WIMMER
Format:	Patent
Sprache:	eng
Schlagworte:	CHEMISTRY DERIVATIVES THEREOF HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY NUCLEIC ACIDS NUCLEOSIDES NUCLEOTIDES ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS STEROIDS SUGARS
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Beschreibung
Zusammenfassung:	PROBLEM TO BE SOLVED: To provide: novel compounds that have utility as inhibitors of heparan sulfate-binding proteins; compositions comprising the compounds; and use of the compounds and the compositions comprising the compounds for the antiangiogenic, antimetastatic, anti-inflammatory, antimicrobial, anticoagulant and/or antithrombotic treatment of a mammalian.SOLUTION: The compounds are oligosaccharide derivatives including 3 -cholestanyl-2,3,4,6-tetra-O-sodium sulfonato-α-D-glucopyranosyl-(1→4)-2,3,6-tri-O-sodium sulfonato-α-D-glucopyranosyl-(1→4)-2,3,6-tri-O-sodium sulfonato-α-D-glucopyranosyl-(1→4)-2,3,6-tri-O-sodium sulfonato- -D-glucopyranoside.