TROPANE COMPOUNDS

PROBLEM TO BE SOLVED: To provide pharmaceutical compositions which inhibit heat shock protein 90 (HSP90) and are useful for treatment of cancer, neurodegenerative diseases, infectious diseases, inflammatory diseases, autoimmune disorders, stroke, ischemia, cardiac disorders, sepsis, fibroproliferati...

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Bibliographische Detailangaben
Hauptverfasser:	ARLYN ARCALAS, JOERG BUSSENIUS, KIM ANGIE INYOUNG, WANG LONGCHENG, JEAN-CLAIRE LIMUN MANALO, NEEL KUMAR ANAND, BOWLES OWEN JOSEPH, CHARLES M BLAZEY, AAY NAING, COSTANZO SIMONA, ABIGAIL R KENNEDY, KATHERINE LARA, LARISA DUBENKO, BUHR CHRIS A, TSANG TSZE H, STEVEN CHARLES DEFINA, BAIK TAE-GON, RICE KENNETH D, CURTIS JEFFRY KIMO, PETO CSABA J, MA SUNGHOON
Format:	Patent
Sprache:	eng
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	PROBLEM TO BE SOLVED: To provide pharmaceutical compositions which inhibit heat shock protein 90 (HSP90) and are useful for treatment of cancer, neurodegenerative diseases, infectious diseases, inflammatory diseases, autoimmune disorders, stroke, ischemia, cardiac disorders, sepsis, fibroproliferative disorders and metabolic diseases.SOLUTION: The pharmaceutical compositions contain tropane compounds having N-pyridyl substituents represented by the specified formula I. Representative examples include 6-[3-endo-({[2-methyl-3-(methyloxy)phenyl]carbonyl}amino)-8-azabicyclo[3.2.1]oct-8-yl]-N-({4-[4-(2-methylpropyl)piperazin-1-yl]phenyl}methyl)pyridine-3-carboxamide.