PAPILLOMAVIRUS VACCINE COMPOSITIONS

PROBLEM TO BE SOLVED: To provide pharmaceutical compositions comprising virus-like particles (VLPs) of human papillomavirus (HPV), said VLPs adsorbed to an aluminum adjuvant, and an ISCOM-type adjuvant comprising a saponin, cholesterol, and a phospholipid.SOLUTION: The aluminum adjuvant comprises am...

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Bibliographische Detailangaben
Hauptverfasser:	MCCLEMENTS WILLIAM L, CASIMIRO DANILO, BRYAN JANINE T, BROWNLOW MICHELLE K, HU BINGHUA, MEYER BRIAN K, SHI LI
Format:	Patent
Sprache:	eng
Schlagworte:	HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	PROBLEM TO BE SOLVED: To provide pharmaceutical compositions comprising virus-like particles (VLPs) of human papillomavirus (HPV), said VLPs adsorbed to an aluminum adjuvant, and an ISCOM-type adjuvant comprising a saponin, cholesterol, and a phospholipid.SOLUTION: The aluminum adjuvant comprises amorphous aluminum hydroxyphosphate sulfate. Another aspect provides multi-dose HPV vaccine formulations, the formulations comprising HPV VLPs and an antimicrobial preservative selected from the group consisting of m-cresol, phenol, and benzyl alcohol. Also provided are methods of using the disclosed pharmaceutical compositions and formulations to induce an immune response against HPV in a human patient and to prevent HPV infection.