METHOD OF PRODUCING TABLETS CONTAINING VALSARTAN

PROBLEM TO BE SOLVED: To provide a method of dry granulating and tableting valsartan, which is a method of producing tablets wherein the method minimizes mass variation among tablets, and which is also a simple production method making their industrial production possible.SOLUTION: A method of producing tablets wherein the method tablets a mixture of granules containing valsartan which are produced by dry granulation and additives for tableting, the method comprising the steps of: in the process of producing the granules produced by dry granulation, (a) roller pressing a mixture of valsartan and additives for granules such as low-substituted hydroxypropyl cellulose, light anhydrous silicic acid, etc., (b) crushing the resultant flakes, (c) granulating, and (d) sieving the resultant granules with a sieve of 60-200 mesh, to obtain residual granules A and transitional granules B, and performing (a) and (b) above again in respect to B to obtain granules C produced by second dry granulation; and tableting a mixture of A and C above and additives for tableting such as crystalline cellulose, magnesium stearate, etc.