DERIVATIVES OF PYRROLIDINE AND PIPERIDINE AS NK1 ANTAGONISTS

PROBLEM TO BE SOLVED: To provide derivatives of pyrrolidine and piperidine as NK1 antagonists.SOLUTION: NK1 antagonists containing the formula (I), where Arand Arare a substituted, if needed, phenyl or heteroaryl, Xis an ether, a thio or an imino bond, Rand Rare both not H or an alkyl, and remaining...

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Bibliographische Detailangaben
Hauptverfasser:	HONUNG TSUI, WROBLESKI MICHELLE LACI, PALANI ANANDAN, PALIWAL SUNIL, XIAO DONG, ARREDONDO JUAN D, WANG QIANG, REICHARD GREGORY A, SHIH NENG-YANG
Format:	Patent
Sprache:	eng
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	PROBLEM TO BE SOLVED: To provide derivatives of pyrrolidine and piperidine as NK1 antagonists.SOLUTION: NK1 antagonists containing the formula (I), where Arand Arare a substituted, if needed, phenyl or heteroaryl, Xis an ether, a thio or an imino bond, Rand Rare both not H or an alkyl, and remaining variables are defined specially in the description are useful for treating many disorders (including vomiting, depression, anxiety and coughing). A treatment method and combination with other factors are also disclosed.