PYRIMIDYL CYCLOPENTANE AS AKT PROTEIN KINASE INHIBITOR

PROBLEM TO BE SOLVED: To provide a new compound inhibiting AKT protein kinase.SOLUTION: Disclosed is a compound in formula I including its tautomers, divided enantiomers, diastereomers, solvates, metabolites, salts and pharmaceutically allowable prodrugs. Also provided is a method for using the comp...

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Bibliographische Detailangaben
Hauptverfasser:	KEITH L SPENCER, MITCHELL IAN S, XIAO DENGMING, CHABOT CHRISTINE, BENCSIK JOSEF R, JAMES F BLAKE, LIANG JUN, SAFINA BRIAN S, RUI XU, KALLEN NICHOLAS C
Format:	Patent
Sprache:	eng
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	PROBLEM TO BE SOLVED: To provide a new compound inhibiting AKT protein kinase.SOLUTION: Disclosed is a compound in formula I including its tautomers, divided enantiomers, diastereomers, solvates, metabolites, salts and pharmaceutically allowable prodrugs. Also provided is a method for using the compound as an AKT protein kinase inhibitor, and also provided is a method for treating hyperproliferative diseases such as cancer. AKT protein kinase-mediated conditions capable of treatment according to this method include inflammatory diseases, hyperproliferative diseases, cardiovascular diseases, neurodegenerative diseases, gynecologic diseases, skin diseases and disorders, but is not limited to them.