COMPOUNDS USEFUL AS RAF KINASE INHIBITORS
PROBLEM TO BE SOLVED: To provide compounds useful as inhibitors of Raf protein kinase.SOLUTION: The present invention provides compounds useful as inhibitors of Raf protein kinase. The present invention also provides compositions thereof, and methods of treating Raf-mediated diseases. It has now bee...
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| creator | JONES JOHN HOWARD TANAKA HIROKO POWELL NOEL RAIMUNDO BRIAN WYNN THOMAS GUAN BING XIN ZHILI COSSROW JENNIFER FRANKLIN LIOYD LUGOVSKOY ALEXEY KUMARAVEL GNANASAMBANDAM LANE BENJAMIN CHEN WEIRONG PENG HAIRUO VESSELS JEFFREY LITTKE ADAM |
| description | PROBLEM TO BE SOLVED: To provide compounds useful as inhibitors of Raf protein kinase.SOLUTION: The present invention provides compounds useful as inhibitors of Raf protein kinase. The present invention also provides compositions thereof, and methods of treating Raf-mediated diseases. It has now been found that compounds, and pharmaceutically acceptable compositions thereof, are effective as inhibitors of one or more protein kinases. In certain other embodiments, the invention provides pharmaceutical compositions comprising a compound, wherein the compound is present in an amount effective to inhibit Raf activity. In certain other embodiments, the invention provides pharmaceutical compositions comprising a compound and optionally further comprising an additional therapeutic agent. In yet other embodiments, the additional therapeutic agent is an agent for the treatment of cancer. |
| format | Patent |
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The present invention also provides compositions thereof, and methods of treating Raf-mediated diseases. It has now been found that compounds, and pharmaceutically acceptable compositions thereof, are effective as inhibitors of one or more protein kinases. In certain other embodiments, the invention provides pharmaceutical compositions comprising a compound, wherein the compound is present in an amount effective to inhibit Raf activity. In certain other embodiments, the invention provides pharmaceutical compositions comprising a compound and optionally further comprising an additional therapeutic agent. 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The present invention also provides compositions thereof, and methods of treating Raf-mediated diseases. It has now been found that compounds, and pharmaceutically acceptable compositions thereof, are effective as inhibitors of one or more protein kinases. In certain other embodiments, the invention provides pharmaceutical compositions comprising a compound, wherein the compound is present in an amount effective to inhibit Raf activity. In certain other embodiments, the invention provides pharmaceutical compositions comprising a compound and optionally further comprising an additional therapeutic agent. In yet other embodiments, the additional therapeutic agent is an agent for the treatment of cancer.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE |
| title | COMPOUNDS USEFUL AS RAF KINASE INHIBITORS |
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