METHOD FOR PRODUCING AMINE DERIVATIVE

PROBLEM TO BE SOLVED: To provide a method for efficiently producing highly pure brinzolamide in a method for producing the brinzolamide by sulfonylating a hydroxy group connected to a carbon atom at the fourth position of (S)-3,4-dihydro-4-hydroxy-2-(3-methoxypropyl)-2H-thieno[3,2-e]-1,2-thiazine-6-...

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Bibliographische Detailangaben
1. Verfasser:	HIRASAWA KOICHI
Format:	Patent
Sprache:	eng
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	PROBLEM TO BE SOLVED: To provide a method for efficiently producing highly pure brinzolamide in a method for producing the brinzolamide by sulfonylating a hydroxy group connected to a carbon atom at the fourth position of (S)-3,4-dihydro-4-hydroxy-2-(3-methoxypropyl)-2H-thieno[3,2-e]-1,2-thiazine-6-sulfonamide-1,1-dioxide to activate it, and then, ethylaminating it.SOLUTION: In a reaction wherein a hydroxy group is activated to be replaced by amine, a sulfonyl chloride compound wherein a methylene group is connected to sulfonyl is used for activation of the hydroxy group.