COMPOUND FOR MODULATING TRPV3 FUNCTION

COMPOUND FOR MODULATING TRPV3 FUNCTION

PROBLEM TO BE SOLVED: To provide methods and compositions that modulate a TRP family member.SOLUTION: The method for treating or preventing a condition involving activation of TRPV3 or for which reduced TRPV3 activity can reduce the severity includes administering a compound in an amount effective t...

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Bibliographische Detailangaben
Hauptverfasser: CHONG JAYHONG A, RIPKA AMY, WEIGELE MANFRED, LUMMA WILLIAM C JR, LARSEN GLENN R, ZHEN XIAOGUANG, MAHADEVAN ANU, FANGER CHRISTOPHER, MORAN MAGDALENA M, UNDERWOOD DENNIS JOHN, MELTZER PETER
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:PROBLEM TO BE SOLVED: To provide methods and compositions that modulate a TRP family member.SOLUTION: The method for treating or preventing a condition involving activation of TRPV3 or for which reduced TRPV3 activity can reduce the severity includes administering a compound in an amount effective to inhibit TRPV3-mediated current with an ICof 1 micromolar or less.