STABILIZED PHARMACEUTICAL COMPOSITION

PROBLEM TO BE SOLVED: To provide a pharmaceutical composition in which the increase in impurities accompanying the preparation of benzimidazole-7-carboxylic acid represented by candesartan or candesartan cilexetil or its derivative is suppressed, and reduction with time in the contents is prevented,...

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Hauptverfasser: MOCHIZUKI RYOSUKE, YASUI MASAMI, IWANE HIDENORI
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creator MOCHIZUKI RYOSUKE
YASUI MASAMI
IWANE HIDENORI
description PROBLEM TO BE SOLVED: To provide a pharmaceutical composition in which the increase in impurities accompanying the preparation of benzimidazole-7-carboxylic acid represented by candesartan or candesartan cilexetil or its derivative is suppressed, and reduction with time in the contents is prevented, and a method for preparing the composition.SOLUTION: The stable pharmaceutical composition can be obtained when benzimidazole-7-carboxylic acid or its derivative is blended with polyhydric alcohol. Namely, technical ethics is established that the addition of polyhydric alcohol remarkably suppresses the decomposition of effective components, suppresses the increase in impurities accompanying the preparation, and prevents the reduction with time in the contents of the effective components.
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subjects HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
title STABILIZED PHARMACEUTICAL COMPOSITION
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