SUBSTITUTED BENZIMIDAZOLE AS KINASE INHIBITOR

PROBLEM TO BE SOLVED: To provide: new substituted benzimidazole compounds, their tautomers, stereoisomers, polymorphs, esters, metabolites, and prodrugs; the pharmaceutically acceptable salts of the compounds, tautomers, stereoisomers, polymorphs, esters, metabolites, and prodrugs; compositions of any of the embodiments together with pharmaceutically acceptable carriers; and uses of any of the embodiments, either alone or in combination with at least one additional therapeutic agent, in the prophylaxis or treatment of cancer.SOLUTION: The new substituted benzimidazole compounds of formula (I), compositions, and methods of inhibition of kinase activity associated with carcinogenicity in a human or animal subject are provided. In certain embodiments, the compounds and compositions are effective to inhibit the activity of at least one serine/threonine kinase or receptor tyrosine kinase. The compounds and compositions may be used either alone or in combination with at least one additional agent for the treatment of a serine/threonine kinase- or receptor tyrosine kinase-mediated disorder, such as cancer.