SOLID ORAL MEDICINAL COMPOSITION AND METHOD FOR PRODUCING THE SAME

PROBLEM TO BE SOLVED: To provide a solid oral medicinal composition from which the leachability of ibuprofen is maintained even after low-temperature preservation, and to provide a method for producing the medicinal composition.SOLUTION: The method for producing the solid oral medicinal composition...

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Bibliographische Detailangaben
Hauptverfasser:	ITO TAKETOSHI, TAKAHASHI CHIAKI, TAKAHATA YUJI, KAGEYAMA MOTOHIRO, OKUI SATOI, IMAI HIROTO
Format:	Patent
Sprache:	eng
Schlagworte:	HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:	PROBLEM TO BE SOLVED: To provide a solid oral medicinal composition from which the leachability of ibuprofen is maintained even after low-temperature preservation, and to provide a method for producing the medicinal composition.SOLUTION: The method for producing the solid oral medicinal composition includes mixing (A) ibuprofen, (B) an aminoalkyl methacrylate copolymer E and (C) a vehicle, heating the obtained mixture under conditions of the heating temperature and heating time satisfying the relationship between the heating temperature (X°C) and the heating time (Y h) represented by Y≥0.0052X-1.114X+60.57 (wherein, X is 50-100; and Y is a value obtained by rounding the number after the decimal point), and pulverizing the obtained heated mixture.