ANTI-ADDL ANTIBODY AND USE THEREOF

PROBLEM TO BE SOLVED: To provide antibodies that differentially recognize multi-dimensional conformations of A -derived diffusible ligands, also known as ADDLs.SOLUTION: Mice were inoculated with ADDLs every three weeks for a total of six inoculations. Positive clones are identified from the hybrido...

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Hauptverfasser:	KINNEY GENE, STROHL WILLIAM R, BREESE ROBERT, SHUGHRUE PAUL, LAMBERT MARY P, DODSON ELIZABETH CHEN, VIOLA KIRSTEN L, ACTON PAUL, KLEIN WILLIAM, CHANG LEI, BETT ANDREW J, AN ZHIQIANG, XIAOPING LIANG
Format:	Patent
Sprache:	eng
Schlagworte:	CHEMISTRY HUMAN NECESSITIES HYGIENE INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEPTIDES PHYSICS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS TESTING
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Beschreibung
Zusammenfassung:	PROBLEM TO BE SOLVED: To provide antibodies that differentially recognize multi-dimensional conformations of A -derived diffusible ligands, also known as ADDLs.SOLUTION: Mice were inoculated with ADDLs every three weeks for a total of six inoculations. Positive clones are identified from the hybridomas made from the fusion of these mice spleens with SP2 cells. The obtained antibodies can distinguish between Alzheimer's Disease and control human brain extracts and are useful in methods of detecting ADDLs and diagnosing Alzheimer's Disease. The antibodies also block binding of ADDLs to neurons, assembly of ADDLs, and tau phosphorylation and are there useful in methods for the preventing and treating diseases associated with soluble oligomers of amyloid 1-42.