PYROGLUTAMATE SALT AND USE OF THE SAME IN OPTICAL RESOLUTION OF INTERMEDIATE FOR SYNTHESIS OF DEXTROCETIRIZINE AND LEVOCETIRIZINE

PYROGLUTAMATE SALT AND USE OF THE SAME IN OPTICAL RESOLUTION OF INTERMEDIATE FOR SYNTHESIS OF DEXTROCETIRIZINE AND LEVOCETIRIZINE

PROBLEM TO BE SOLVED: To provide a simpler preparation method for an enantiomerically and essentially pure compound like levocetirizine or the like by using a novel and enantiomerically and essentially pure intermediate.SOLUTION: There is provided a (S)-2-[4-(4-chlorobenzhydryl)piperazine-1-yl]-etho...

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Bibliographische Detailangaben
Hauptverfasser: ATES CELAL, PALACIO MAGALI
Format: Patent
Sprache:eng
Schlagworte:
APPARATUS THEREFOR
CHEMISTRY
GENERAL METHODS OF ORGANIC CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Zusammenfassung:PROBLEM TO BE SOLVED: To provide a simpler preparation method for an enantiomerically and essentially pure compound like levocetirizine or the like by using a novel and enantiomerically and essentially pure intermediate.SOLUTION: There is provided a (S)-2-[4-(4-chlorobenzhydryl)piperazine-1-yl]-ethoxyacetamide-(S)-pyrrolidone-5-carboxylic acid salt, (R)-2-[4-(4-chlorobenzhydryl)piperazine-1-yl]-ethoxyacetamide-(S)-pyrrolidone-5-carboxylic acid salt, (S)-2-[4-(4-chlorobenzhydryl)piperazine-1-yl]-ethoxyacetamide-(R)-pyrrolidone-5-carboxylic acid salt, or (R)-2-[4-(4-chlorobenzhydryl)piperazine-1-yl]-ethoxyacetamide-(R)-pyrrolidone-5-carboxylic acid salt. There is also provided the preparation method for (S)-2-[4-(4-chlorobenzhydryl)piperazine-1-yl]-ethoxyacetamide (I) and (R)-2-[4-(4-chlorobenzhydryl)piperazine-1-yl]-ethoxyacetamide (II) by chemical resolution of a mixture.