METALLO- -LACTAMASE INHIBITOR

PROBLEM TO BE SOLVED: To provide a metallo- -lactamase inhibitor which acts as a medicament for inhibiting the inactivation of a -lactam antibiotic and recovering the antibacterial activity.SOLUTION: A maleic acid derivative having a structure of general formula (I) has an inhibitory activity agains...

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Bibliographische Detailangaben
Hauptverfasser: MORINAKA AKIHIRO, ABE TAKAO, KUDO TOSHIAKI, KONNAI TAKESHI, IDA MIZUYO, HIRAIWA YUKIKO
Format: Patent
Sprache:eng
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Zusammenfassung:PROBLEM TO BE SOLVED: To provide a metallo- -lactamase inhibitor which acts as a medicament for inhibiting the inactivation of a -lactam antibiotic and recovering the antibacterial activity.SOLUTION: A maleic acid derivative having a structure of general formula (I) has an inhibitory activity against the metallo- -lactamase. The antibacterial activity of the -lactam antibiotic against metallo- -lactamase-producing bacteria can be recovered by combining the compound of general formula (I) with the -lactam antibiotic.