METHOD FOR DETECTING proBNP BY USING MONOCLONAL ANTIBODY BONDING TO AMINO ACID 41-46

PROBLEM TO BE SOLVED: To provide a more specific assay for the measurement of N terminus proBNP and/or a fragment or a subset clinically related to N terminus proBNP.SOLUTION: An antibody bonding specifically to unmodified proBNP correlates to the antibody produced by hybridoma cell line MAB 1.21.3...

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Hauptverfasser: GALLUSSER ANDREAS, KLEMT VOLKER, SEIDEL CHRISTOPH, HALLERMAYER KLAUS, GROL MICHAEL, BORGYA ANNELIESE
Format: Patent
Sprache:eng
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Zusammenfassung:PROBLEM TO BE SOLVED: To provide a more specific assay for the measurement of N terminus proBNP and/or a fragment or a subset clinically related to N terminus proBNP.SOLUTION: An antibody bonding specifically to unmodified proBNP correlates to the antibody produced by hybridoma cell line MAB 1.21.3 (DSM ACC2650) of r=0.95 or larger value when it is decided by the linear regression analysis for the value of unmodified proBNP measured in the heart failure patient sample which has N terminus (1-76) unmodified proBNP of 10 to 150 ng/ml, and has a bonding affinity of at least 10L/mol to the unmodified proBNP.