ANTI-HISTAMINE COMPOSITIONS AND USE THEREOF

ANTI-HISTAMINE COMPOSITIONS AND USE THEREOF

PROBLEM TO BE SOLVED: To provide a storage-stable pharmaceutical liquid solution for oral administration having a pharmaceutically effective amount of an antihistamine and having a purity equal to or greater than about 99 mass% based on HPLC assay, residual solvents of less than about 0.5%, and a to...

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Bibliographische Detailangaben
Hauptverfasser: ZADYKOWICZ JERZY, ASOTRA SATISH, VANAM KALPANA R, GAO SHEN
Format: Patent
Sprache:eng
Schlagworte:
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Zusammenfassung:PROBLEM TO BE SOLVED: To provide a storage-stable pharmaceutical liquid solution for oral administration having a pharmaceutically effective amount of an antihistamine and having a purity equal to or greater than about 99 mass% based on HPLC assay, residual solvents of less than about 0.5%, and a total impurity of less than about 0.2%.SOLUTION: The formulation having high purity and an elongated storage time includes a spill resistant cetirizine formulation containing high levels of low molecule weight polyhydric alcohol not forming most common cetirizine formulation degradative products.