DELIVERY SYSTEM AND METHOD USING PREFORMED BIODEGRADABLE POLYMER COMPOSITION

PROBLEM TO BE SOLVED: To provide a delivery system for delivering active agents to a subject, which can provide various biodegradation and delivery rates.SOLUTION: The delivery system uses a preformed biodegradable polymer composition represented by a formula of I-(-X-LM-G)n [wherein X is a bifuncti...

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Hauptverfasser:	FERBER RICHARD H, POURNOOR KAVEH, VELASQUEZ DAVID J, TRUONG MYHANH T, CHOI HYE-OK, BERNATCHEZ STEPHANIE F
Format:	Patent
Sprache:	eng
Schlagworte:	CHEMISTRY COMPOSITIONS BASED THEREON HUMAN NECESSITIES HYGIENE MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONSONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC MACROMOLECULAR COMPOUNDS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS THEIR PREPARATION OR CHEMICAL WORKING-UP
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Beschreibung
Zusammenfassung:	PROBLEM TO BE SOLVED: To provide a delivery system for delivering active agents to a subject, which can provide various biodegradation and delivery rates.SOLUTION: The delivery system uses a preformed biodegradable polymer composition represented by a formula of I-(-X-LM-G)n [wherein X is a bifunctional polyoxyethylene chain portion or bond ; LM is a bifunctional connecting part represented by -C(O)-, -(CH2)bC(O)- (b is an integer of 1 to 5), -C(O)-(CH)c-C(O)- (c is an integer of 2 to 10) or -C(O)-O-(CH)d-O-C(O)- (d is an integer of 2 to 10)]; G is a leaving group such as N-oxysuccinimidyl ; and I is a multifunctional connecting part induced from a multnucleophilic compound, and is a crosslinked albumin desolvated at least partially.