RAPIDLY DISSOLVING ROBUST DOSAGE FORM

RAPIDLY DISSOLVING ROBUST DOSAGE FORM

PROBLEM TO BE SOLVED: To provide a hard tablet that can be stored, packaged and processed in bulk.SOLUTION: The tablet is created from an active ingredient mixed into a matrix of an indirect compression filler and a relatively high lubricant content. Preferably, the tablet also contains a matrix hav...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: CHASTAIN SARA J, KHANKARI RAJENDRA K, HONTZ JOHN, KATZNER LEO
Format: Patent
Sprache:eng
Schlagworte:
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:PROBLEM TO BE SOLVED: To provide a hard tablet that can be stored, packaged and processed in bulk.SOLUTION: The tablet is created from an active ingredient mixed into a matrix of an indirect compression filler and a relatively high lubricant content. Preferably, the tablet also contains a matrix having the indirect compression filler, a wicking agent, and a hydrophobic lubricant. The matrix of the tablet contains a rapid water-soluble ingredient in at least about 60% based on the total weight of the matrix material. It is preferable that the tablet dissolves rapidly in the mouth of the patient with a minimum of grit.