LIQUID, AQUEOUS PHARMACEUTICAL COMPOSITION OF FACTOR VII POLYPEPTIDE

PROBLEM TO BE SOLVED: To provide liquid, aqueous pharmaceutical compositions of Factor VII polypeptides which provides acceptable control of chemical and/or physical degradation products such as enzymatic degradation or autocatalysis products.SOLUTION: The present invention relates to a liquid, aque...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser:	JENSEN MICHAEL BECH, JAKOBSEN KIRSTEN KRAMER, HANSEN BIRTHE LYKKEGAARD, KORNFELT TROELS
Format:	Patent
Sprache:	eng
Schlagworte:	CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	PROBLEM TO BE SOLVED: To provide liquid, aqueous pharmaceutical compositions of Factor VII polypeptides which provides acceptable control of chemical and/or physical degradation products such as enzymatic degradation or autocatalysis products.SOLUTION: The present invention relates to a liquid, aqueous pharmaceutical composition comprising a Factor VII polypeptide (i); a buffering agent (ii) suitable for keeping a pH in the range of from about 4.0 to about 9.0; at least one metal-containing agent (iii), wherein the metal is selected from the group consisting of first transition series metals of oxidation state +II, except zinc, such as chromium, manganese, iron, cobalt, nickel, and copper; and a non-ionic surfactant (iv).