METHOD FOR SYNTHESIZING OLIGONUCLEOTIDE USING HIGHLY DISPERSIBLE LIQUID PHASE SUPPORT

PROBLEM TO BE SOLVED: To provide a method for synthesizing a nucleic acid, with which a reaction can be conducted in a fluid (flow) and improved coupling efficiency is brought about, by using a highly dispersible liquid phase support.SOLUTION: In the method for synthesizing an oligonucleotide, a hydrophobic group-linked nucleoside of formula (1) [in the formula, Ris a 1C-12C alkylene group, Ris a 1C-22C alkylene group, each of Rand Ris independently a 1C-22C alkyl group and so on, Ris a single bond or a 1C-22C alkylene group, each of Ris independently a 6C-30C alkyl group, n is 2-6, X is a hydrogen atom, a hydroxyl group, and so on, and Z is an adenyl group, a guanyl group, and so on, the polar group of which is optionally protected] or an oligonucleotide and a nucleoside phosphoroamidite dissolved in a nonpolar solvent are brought into contact with an acid-azole complex compound or a solution thereof.