METHOD FOR SCREENING ANTICANCER SUBSTANCE INHIBITING FUNCTION OF TM4SF5 AND ANTICANCER COMPOSITION CONTAINING CHALCONE-BASED COMPOUND
PROBLEM TO BE SOLVED: To provide a method for screening an anticancer substance inhibiting TM4SF5-mediated tumor formation, development and metastasis, to provide the anticancer substance screened using the method, especially a sulfonamide or sulfonate chalcone-based compound, and to provide an anti...
Gespeichert in:
| Hauptverfasser: | , , , , |
|---|---|
| Format: | Patent |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext bestellen |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | |
| container_start_page | |
| container_title | |
| container_volume | |
| creator | I JONWON PARK KI HUN RYU YOUNG BAE LEE SIN-AE RYU HYUNG WON |
| description | PROBLEM TO BE SOLVED: To provide a method for screening an anticancer substance inhibiting TM4SF5-mediated tumor formation, development and metastasis, to provide the anticancer substance screened using the method, especially a sulfonamide or sulfonate chalcone-based compound, and to provide an anticancer composition containing the anticancer compound as an effective ingredient.SOLUTION: The present invention relates to the method for screening an anticancer substance, comprising: culturing cancer cells expressing the oncogenic protein TM4SF5 (transmembrane 4 L6 family member 5) expressing the polypeptide of a specific sequence; treating the cancer cells with an anticancer candidate substance, and screening the substance exhibiting antagonistic activity against tumor formation and metastasis based on several events through various molecular mechanisms relating to the expression of TM4SF5, as the anticancer substance. The present invention also relates to chalcone-based compounds screened using the method, and an anticancer composition comprising the compound as an effective ingredient. |
| format | Patent |
| fullrecord | <record><control><sourceid>epo_EVB</sourceid><recordid>TN_cdi_epo_espacenet_JP2012100668A</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>JP2012100668A</sourcerecordid><originalsourceid>FETCH-epo_espacenet_JP2012100668A3</originalsourceid><addsrcrecordid>eNqNjLEOgjAQhlkcjPoOjTsJoBLXcm3tGbkSesyEmDoZJcFX8L0FdXB0urv__76bR89Ss3VKGFcLD7XWhHQQkhhBEugxbArP0yqQLBbIU28aAkZHwhnB5dab3aioXw1cWTmPbwgcscT3Y7DyNJ46LqTX6kM1pJbR7NJdh7D6zkW0NprBxqG_t2Hou3O4hUd7rLIkzdIkyfO93PwFvQAWEj30</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>patent</recordtype></control><display><type>patent</type><title>METHOD FOR SCREENING ANTICANCER SUBSTANCE INHIBITING FUNCTION OF TM4SF5 AND ANTICANCER COMPOSITION CONTAINING CHALCONE-BASED COMPOUND</title><source>esp@cenet</source><creator>I JONWON ; PARK KI HUN ; RYU YOUNG BAE ; LEE SIN-AE ; RYU HYUNG WON</creator><creatorcontrib>I JONWON ; PARK KI HUN ; RYU YOUNG BAE ; LEE SIN-AE ; RYU HYUNG WON</creatorcontrib><description>PROBLEM TO BE SOLVED: To provide a method for screening an anticancer substance inhibiting TM4SF5-mediated tumor formation, development and metastasis, to provide the anticancer substance screened using the method, especially a sulfonamide or sulfonate chalcone-based compound, and to provide an anticancer composition containing the anticancer compound as an effective ingredient.SOLUTION: The present invention relates to the method for screening an anticancer substance, comprising: culturing cancer cells expressing the oncogenic protein TM4SF5 (transmembrane 4 L6 family member 5) expressing the polypeptide of a specific sequence; treating the cancer cells with an anticancer candidate substance, and screening the substance exhibiting antagonistic activity against tumor formation and metastasis based on several events through various molecular mechanisms relating to the expression of TM4SF5, as the anticancer substance. The present invention also relates to chalcone-based compounds screened using the method, and an anticancer composition comprising the compound as an effective ingredient.</description><language>eng</language><subject>ACYCLIC OR CARBOCYCLIC COMPOUNDS ; BEER ; BIOCHEMISTRY ; CHEMISTRY ; COMPOSITIONS OR TEST PAPERS THEREFOR ; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES ; ENZYMOLOGY ; HUMAN NECESSITIES ; HYGIENE ; INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES ; MEASURING ; MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; MICROBIOLOGY ; MUTATION OR GENETIC ENGINEERING ; ORGANIC CHEMISTRY ; PHYSICS ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; PROCESSES OF PREPARING SUCH COMPOSITIONS ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS ; SPIRITS ; TESTING ; VINEGAR ; WINE</subject><creationdate>2012</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20120531&DB=EPODOC&CC=JP&NR=2012100668A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25542,76290</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20120531&DB=EPODOC&CC=JP&NR=2012100668A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>I JONWON</creatorcontrib><creatorcontrib>PARK KI HUN</creatorcontrib><creatorcontrib>RYU YOUNG BAE</creatorcontrib><creatorcontrib>LEE SIN-AE</creatorcontrib><creatorcontrib>RYU HYUNG WON</creatorcontrib><title>METHOD FOR SCREENING ANTICANCER SUBSTANCE INHIBITING FUNCTION OF TM4SF5 AND ANTICANCER COMPOSITION CONTAINING CHALCONE-BASED COMPOUND</title><description>PROBLEM TO BE SOLVED: To provide a method for screening an anticancer substance inhibiting TM4SF5-mediated tumor formation, development and metastasis, to provide the anticancer substance screened using the method, especially a sulfonamide or sulfonate chalcone-based compound, and to provide an anticancer composition containing the anticancer compound as an effective ingredient.SOLUTION: The present invention relates to the method for screening an anticancer substance, comprising: culturing cancer cells expressing the oncogenic protein TM4SF5 (transmembrane 4 L6 family member 5) expressing the polypeptide of a specific sequence; treating the cancer cells with an anticancer candidate substance, and screening the substance exhibiting antagonistic activity against tumor formation and metastasis based on several events through various molecular mechanisms relating to the expression of TM4SF5, as the anticancer substance. The present invention also relates to chalcone-based compounds screened using the method, and an anticancer composition comprising the compound as an effective ingredient.</description><subject>ACYCLIC OR CARBOCYCLIC COMPOUNDS</subject><subject>BEER</subject><subject>BIOCHEMISTRY</subject><subject>CHEMISTRY</subject><subject>COMPOSITIONS OR TEST PAPERS THEREFOR</subject><subject>CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES</subject><subject>ENZYMOLOGY</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES</subject><subject>MEASURING</subject><subject>MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>MICROBIOLOGY</subject><subject>MUTATION OR GENETIC ENGINEERING</subject><subject>ORGANIC CHEMISTRY</subject><subject>PHYSICS</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>PROCESSES OF PREPARING SUCH COMPOSITIONS</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><subject>SPIRITS</subject><subject>TESTING</subject><subject>VINEGAR</subject><subject>WINE</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2012</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqNjLEOgjAQhlkcjPoOjTsJoBLXcm3tGbkSesyEmDoZJcFX8L0FdXB0urv__76bR89Ss3VKGFcLD7XWhHQQkhhBEugxbArP0yqQLBbIU28aAkZHwhnB5dab3aioXw1cWTmPbwgcscT3Y7DyNJ46LqTX6kM1pJbR7NJdh7D6zkW0NprBxqG_t2Hou3O4hUd7rLIkzdIkyfO93PwFvQAWEj30</recordid><startdate>20120531</startdate><enddate>20120531</enddate><creator>I JONWON</creator><creator>PARK KI HUN</creator><creator>RYU YOUNG BAE</creator><creator>LEE SIN-AE</creator><creator>RYU HYUNG WON</creator><scope>EVB</scope></search><sort><creationdate>20120531</creationdate><title>METHOD FOR SCREENING ANTICANCER SUBSTANCE INHIBITING FUNCTION OF TM4SF5 AND ANTICANCER COMPOSITION CONTAINING CHALCONE-BASED COMPOUND</title><author>I JONWON ; PARK KI HUN ; RYU YOUNG BAE ; LEE SIN-AE ; RYU HYUNG WON</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_JP2012100668A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng</language><creationdate>2012</creationdate><topic>ACYCLIC OR CARBOCYCLIC COMPOUNDS</topic><topic>BEER</topic><topic>BIOCHEMISTRY</topic><topic>CHEMISTRY</topic><topic>COMPOSITIONS OR TEST PAPERS THEREFOR</topic><topic>CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES</topic><topic>ENZYMOLOGY</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES</topic><topic>MEASURING</topic><topic>MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>MICROBIOLOGY</topic><topic>MUTATION OR GENETIC ENGINEERING</topic><topic>ORGANIC CHEMISTRY</topic><topic>PHYSICS</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>PROCESSES OF PREPARING SUCH COMPOSITIONS</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><topic>SPIRITS</topic><topic>TESTING</topic><topic>VINEGAR</topic><topic>WINE</topic><toplevel>online_resources</toplevel><creatorcontrib>I JONWON</creatorcontrib><creatorcontrib>PARK KI HUN</creatorcontrib><creatorcontrib>RYU YOUNG BAE</creatorcontrib><creatorcontrib>LEE SIN-AE</creatorcontrib><creatorcontrib>RYU HYUNG WON</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>I JONWON</au><au>PARK KI HUN</au><au>RYU YOUNG BAE</au><au>LEE SIN-AE</au><au>RYU HYUNG WON</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>METHOD FOR SCREENING ANTICANCER SUBSTANCE INHIBITING FUNCTION OF TM4SF5 AND ANTICANCER COMPOSITION CONTAINING CHALCONE-BASED COMPOUND</title><date>2012-05-31</date><risdate>2012</risdate><abstract>PROBLEM TO BE SOLVED: To provide a method for screening an anticancer substance inhibiting TM4SF5-mediated tumor formation, development and metastasis, to provide the anticancer substance screened using the method, especially a sulfonamide or sulfonate chalcone-based compound, and to provide an anticancer composition containing the anticancer compound as an effective ingredient.SOLUTION: The present invention relates to the method for screening an anticancer substance, comprising: culturing cancer cells expressing the oncogenic protein TM4SF5 (transmembrane 4 L6 family member 5) expressing the polypeptide of a specific sequence; treating the cancer cells with an anticancer candidate substance, and screening the substance exhibiting antagonistic activity against tumor formation and metastasis based on several events through various molecular mechanisms relating to the expression of TM4SF5, as the anticancer substance. The present invention also relates to chalcone-based compounds screened using the method, and an anticancer composition comprising the compound as an effective ingredient.</abstract><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext_linktorsrc |
| identifier | |
| ispartof | |
| issn | |
| language | eng |
| recordid | cdi_epo_espacenet_JP2012100668A |
| source | esp@cenet |
| subjects | ACYCLIC OR CARBOCYCLIC COMPOUNDS BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS OR TEST PAPERS THEREFOR CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES ENZYMOLOGY HUMAN NECESSITIES HYGIENE INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PHYSICS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROCESSES OF PREPARING SUCH COMPOSITIONS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS TESTING VINEGAR WINE |
| title | METHOD FOR SCREENING ANTICANCER SUBSTANCE INHIBITING FUNCTION OF TM4SF5 AND ANTICANCER COMPOSITION CONTAINING CHALCONE-BASED COMPOUND |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-02T19%3A37%3A13IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-epo_EVB&rft_val_fmt=info:ofi/fmt:kev:mtx:patent&rft.genre=patent&rft.au=I%20JONWON&rft.date=2012-05-31&rft_id=info:doi/&rft_dat=%3Cepo_EVB%3EJP2012100668A%3C/epo_EVB%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/&rfr_iscdi=true |