COMPOSITION AND METHOD FOR TREATING GLOMERULONEPHRITIS AND OTHER INFLAMMATORY DISEASES

PROBLEM TO BE SOLVED: To provide a new approach for reducing glomerular inflammation and renal dysfunction associated with glomerulonephritis (GN).SOLUTION: There are provided: a nucleic acid molecule comprising a nucleotide sequence encoding scFv polypeptide containing a specific amino acid sequenc...

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Hauptverfasser:	SQUINTO STEPHEN P, NYE STEVEN H, EVANS MARK J, MATIS LOUIS, WANG YI, THOMAS THOMAS C, SPRINGHORN JEREMY P, ROLLINS SCOTT, WILKINS JAMES A, MUELLER EILEEN ELLIOTT, ROTHER RUSSELL P
Format:	Patent
Sprache:	eng
Schlagworte:	AGRICULTURE ANIMAL HUSBANDRY BEER BIOCHEMISTRY CARE OF BIRDS, FISHES, INSECTS CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA DERIVATIVES THEREOF ENZYMOLOGY FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE FISHING FORESTRY HUMAN NECESSITIES HUNTING HYGIENE INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING NEW BREEDS OF ANIMALS NUCLEIC ACIDS NUCLEOSIDES NUCLEOTIDES ORGANIC CHEMISTRY PEPTIDES PHYSICS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS SUGARS TESTING TRAPPING VINEGAR WINE
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Beschreibung
Zusammenfassung:	PROBLEM TO BE SOLVED: To provide a new approach for reducing glomerular inflammation and renal dysfunction associated with glomerulonephritis (GN).SOLUTION: There are provided: a nucleic acid molecule comprising a nucleotide sequence encoding scFv polypeptide containing a specific amino acid sequence; a nucleic acid molecule comprising a nucleotide sequence encoding polypeptide containing a specific variable light chain region amino acid sequence corresponding to amino acid 3 to amino acid 110; a nucleic acid molecule comprising a nucleotide sequence encoding polypeptide containing a specific variable heavy chain region amino acid sequence corresponding to amino acid 1 to amino acid 122; or an isolated protein comprising (a) a first polypeptide region containing a specific variable light chain region amino acid sequence corresponding to amino acid 3 to amino acid 110 and (b) a second polypeptide region containing a specific variable heavy chain region amino acid sequence corresponding to amino acid 1 to amino acid 122.