CONDENSED AZA BICYCLIC COMPOUND INHIBITING VANILLOID RECEPTOR SUBTYPE 1 (VR1) RECEPTOR

PROBLEM TO BE SOLVED: To provide a novel VR1 antagonist useful for treatment of pain, inflammatory thermalgesia, urorrhea and bladder hyperactivity.SOLUTION: The compound is represented by formula (I) (wherein Xto Xare each a nitrogen atom or the like; R, Rand Rare each a hydrogen atom or the like;...

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Bibliographische Detailangaben
Hauptverfasser:	WHITE TAMMIE K, DIDOMENICO STANLEY JR, GOMTSYAN ARTHUR R, BAYBURT EROL K, PERNER RICHARD J, KOENIG JOHN R, SCHMIDT ROBERT G JR, LEE CHIH-HUNG, DRIZIN IRENE, ZHENG GUO ZHU, TURNER SEAN C
Format:	Patent
Sprache:	eng
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	PROBLEM TO BE SOLVED: To provide a novel VR1 antagonist useful for treatment of pain, inflammatory thermalgesia, urorrhea and bladder hyperactivity.SOLUTION: The compound is represented by formula (I) (wherein Xto Xare each a nitrogen atom or the like; R, Rand Rare each a hydrogen atom or the like; Zand Zare each an oxygen atom or the like; and L is an alkenylene or the like).