INDOLE DERIVATIVE AND USE OF THE SAME AS KINASE INHIBITOR, IN PARTICULAR AS IKK2 INHIBITOR

INDOLE DERIVATIVE AND USE OF THE SAME AS KINASE INHIBITOR, IN PARTICULAR AS IKK2 INHIBITOR

PROBLEM TO BE SOLVED: To provide a therapeutic agent for inflammatory and tissue repair disorders, the therapeutic agent having inhibiting activity of kinase activity, in particular IKK2 activity.SOLUTION: An indole carboxamide compound of a formula (I) is provided. In the formula, R1 represents H,...

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Hauptverfasser: LONGSTAFF TIMOTHY, BAMBOROUGH PAUL, KERNS JEFFREY K, CHRISTOPHER JOHN ANDREW, MILLER DAVID DRYSDALE, BALDWIN IAN ROBERT
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Zusammenfassung:PROBLEM TO BE SOLVED: To provide a therapeutic agent for inflammatory and tissue repair disorders, the therapeutic agent having inhibiting activity of kinase activity, in particular IKK2 activity.SOLUTION: An indole carboxamide compound of a formula (I) is provided. In the formula, R1 represents H, halogen or a group -YZ; Y represents a bond (that is, being absent) or 1-6C alkylene or 2-6C alkenylene; Z represents an aryl or heteroaryl group each including 5 to 14 ring members; R2 represents H or halogen or a group -Y1Z1; Y1 represents a bond (that is, being absent) or 1-6C alkylene, 2-6C alkenylene; Z1 represents a 6-membered aryl, 5- or 6-membered heteroaryl, 5 to 7-membered heterocycle, 5-7C cycloalkyl, 5-7C cycloalkenyl, or the like.