NOVEL METHOD OF TREATMENT

PROBLEM TO BE SOLVED: To provide a new dosage regiment for amoxicillin/clavulanate giving optimized pharmacokinetic profile for amoxicillin while not compromising the bioavailability of clavulanate, so that therapy is maximized, particularily against more resistant bacteria while the (further) devel...

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Bibliographische Detailangaben
Hauptverfasser:	STORM KEVIN H, ROUSH JOHN A, CONLEY CREIGHTON P
Format:	Patent
Sprache:	eng
Schlagworte:	HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	PROBLEM TO BE SOLVED: To provide a new dosage regiment for amoxicillin/clavulanate giving optimized pharmacokinetic profile for amoxicillin while not compromising the bioavailability of clavulanate, so that therapy is maximized, particularily against more resistant bacteria while the (further) development of resistance is minimized.SOLUTION: Bacterial infection may be treated using a high dosage regimen of amoxicillin and potassium clavulanate. The dosage is provided by a bilayer tablet. In particular, the immediate release and slow release compression blend may then be compressed as separate layers on a bilayer tablet press, to form a bilayer tablet.