AROMATIC-SUBSTITUTED XANTHENE DYE

PROBLEM TO BE SOLVED: To provide the independent detection of multiple spatially overlapping analytes in a mixture, e.g., single-tube multiplex DNA probe assays, immunoassays, multicolor DNA sequencing methods, and the like, as required in many important applications. SOLUTION: A class of aromatic-s...

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Bibliographische Detailangaben
Hauptverfasser:	BENSON SCOTT CONRAD, THEISEN PETER DAVID, MENCHEN STEVEN MICHAEL, UPADHYA KRISHNA GAJANAN, HAUSER JOAN DALE
Format:	Patent
Sprache:	eng
Schlagworte:	ADHESIVES BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS OR TEST PAPERS THEREFOR COMPOSITIONS THEREOF CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES CULTURE MEDIA DERIVATIVES THEREOF DYES ENZYMOLOGY HETEROCYCLIC COMPOUNDS INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES LAKES MATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FORELSEWHERE MEASURING MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MISCELLANEOUS APPLICATIONS OF MATERIALS MISCELLANEOUS COMPOSITIONS MORDANTS MUTATION OR GENETIC ENGINEERING NATURAL RESINS NUCLEIC ACIDS NUCLEOSIDES NUCLEOTIDES ORGANIC CHEMISTRY ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES PAINTS PHYSICS POLISHES PROCESSES OF PREPARING SUCH COMPOSITIONS PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS SUGARS TESTING VINEGAR WINE
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Beschreibung
Zusammenfassung:	PROBLEM TO BE SOLVED: To provide the independent detection of multiple spatially overlapping analytes in a mixture, e.g., single-tube multiplex DNA probe assays, immunoassays, multicolor DNA sequencing methods, and the like, as required in many important applications. SOLUTION: A class of aromatic-substituted xanthene compounds useful as fluorescent dyes is disclosed, the compounds having the general structure (I) where Y1and Y2taken separately are selected from the group consisting of hydroxyl, oxygen, iminium, linking group, and amine, or Y1taken together with R2is cyclic imine, or Y2taken together with R3is cyclic amine; R2, R3, R5, and R7are independently selected from the group consisting of hydrogen, fluorine, chlorine, lower alkyl, lower alkene, lower alkyne, sulfonate, sulfone, amino, iminium, amido, nitrile, lower alkoxy, phenyl, and linking group. COPYRIGHT: (C)2011,JPO&INPIT