MICROFLUIDIZED OIL-IN-WATER EMULSION AND VACCINE COMPOSITION

PROBLEM TO BE SOLVED: To provide submicron oil-in-water emulsions useful as a vaccine adjuvant for enhancing the immunogenicity of antigens. SOLUTION: In the submicron oil-in-water emulsions, the antigen is a viral antigen, a bacterial antigen, or a combination thereof, the adjuvant is Quil A, chole...

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Hauptverfasser:	KREBS RICHARD LEE, MANNAN RAMASAMY MANNAR, KLOSE PAMELA KAY, DOMINOWSKI PAUL JOSEPH
Format:	Patent
Sprache:	eng
Schlagworte:	HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Zusammenfassung:	PROBLEM TO BE SOLVED: To provide submicron oil-in-water emulsions useful as a vaccine adjuvant for enhancing the immunogenicity of antigens. SOLUTION: In the submicron oil-in-water emulsions, the antigen is a viral antigen, a bacterial antigen, or a combination thereof, the adjuvant is Quil A, cholesterol, GPI-0100, dimethyldioctadecylammonium bromide, etc. Vaccine compositions contain the antigen combined with the emulsion intrinsically or extrinsically. Furthermore, a method for making the emulsion and vaccine is provided. COPYRIGHT: (C)2011,JPO&INPIT