DIAMINOTRIAZOLE USEFUL AS INHIBITOR OF PROTEIN KINASE

DIAMINOTRIAZOLE USEFUL AS INHIBITOR OF PROTEIN KINASE

PROBLEM TO BE SOLVED: To provide compounds effective as inhibitors of FLT-3, FMS, c-KIT, PDGFR, JAK, AGC subfamily of protein kinase (such as PKA, PDK, p70S6K-1 and -2, and PKB), CDK, GSK, SRC, ROCK and/or SYK protein kinase, and to provide pharmaceutically acceptable compositions thereof. SOLUTION:...

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Hauptverfasser: PIERCE ALBERT C, ARNOST MICHAEL, SALITURO FRANCESCO G, LEDEBOER MARK, NANTHAKUMAR SUGANTHI, GALULLO VINCENT, BINCH HALEY, LEDFORD BRIAN, JAYARAJ ANDREW, DAVIES ROBERT J, FORSTER CORNELIA J, XU JINWANG, WANG JIAN, GREY RONALD, TIAN SHI-KAI, HENKEL GREG, MESSERSMITH DAVID
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Zusammenfassung:PROBLEM TO BE SOLVED: To provide compounds effective as inhibitors of FLT-3, FMS, c-KIT, PDGFR, JAK, AGC subfamily of protein kinase (such as PKA, PDK, p70S6K-1 and -2, and PKB), CDK, GSK, SRC, ROCK and/or SYK protein kinase, and to provide pharmaceutically acceptable compositions thereof. SOLUTION: There are provided protein kinases of formula I. Pharmaceutical compositions containing the compounds, and use methods of the compositions in various diseases are also provided. In specific embodiments, these compounds are effective as inhibitors of FLT-3, JAK-3, PDK-1 and/or SYK protein kinase. COPYRIGHT: (C)2011,JPO&INPIT