SYSTEM AND METHOD FOR PROMOTING CELL ALTERATION USING MICROBUBBLES-CONTAINING LIQUID COMPOSITION

PROBLEM TO BE SOLVED: To attain: (1) the further massiveness and higher speed of cell culture/cell proliferation; and (2) the practical mass acquisition (mass production) of iPS cells by "piPS cell technique". SOLUTION: A system is provided, including the following process: a microbubbles suspension state suitable to various cells is formed using a composition obtained by gas-bubbling with a micro-bubbler in a culture solution; further, regarding object cells, respective individual gas components and their concentrations corresponding to the respective individual take-up easinesses of a plurality of substances needing to promote the alterations of the cells themselves are experimentally determined in advance; and regarding the gas components and their concentrations corresponding to the thus experimentally determined take-up easinesses of the plurality of substances, gas component instructions are given sequentially and individually as time elapses in such an order as substance take-up easiness or difficulty. COPYRIGHT: (C)2011,JPO&INPIT