USE OF DOUBLE-STRANDED DNA RECOGNITION MECHANISM THROUGH EXTRACHROMOSOMAL HISTONE H2B

PROBLEM TO BE SOLVED: To minutely clarify a mechanism for recognizing double-stranded DNA in a natural immune mechanism. SOLUTION: It is clarified that histone H2B has not only a role as nucleosome formation but also an important role for I type interferon production by recognizing foreign double-st...

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Hauptverfasser:	KOHIYAMA KOJI, TAKESHITA FUMIHIKO, YOSHIDA TOKUJI
Format:	Patent
Sprache:	eng
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PHYSICS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS TESTING VINEGAR WINE
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Beschreibung
Zusammenfassung:	PROBLEM TO BE SOLVED: To minutely clarify a mechanism for recognizing double-stranded DNA in a natural immune mechanism. SOLUTION: It is clarified that histone H2B has not only a role as nucleosome formation but also an important role for I type interferon production by recognizing foreign double-stranded DNA and activating an intracellular signal. The complex of extrachromosomal histone H2B and a double-stranded DNA is provided. The method for screening a regulator of a complex of extrachromosomal histone H2B and a double-stranded DNA is provided. The method for screening a regulator of an intracellular signaling by a complex of extrachromosomal histone H2B and a double-stranded DNA is provided. COPYRIGHT: (C)2011,JPO&INPIT