BENZODIAZEPINE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

BENZODIAZEPINE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

PROBLEM TO BE SOLVED: To provide a medicine used for treating or preventing a respirator syncytium virus (RSV) infection. SOLUTION: Benzodiazepine derivative of formula (I), and pharmaceutically acceptable salts thereof, are found to be active against RSV. In the formula: R1represents aryl, heteroar...

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Bibliographische Detailangaben
Hauptverfasser: TYMS STAN, TAYLOR DEBRA, CARTER MALCOLM, HENDERSON ELISA, KELSEY RICHARD, WILSON LARA, CHAMBERS PHIL
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Zusammenfassung:PROBLEM TO BE SOLVED: To provide a medicine used for treating or preventing a respirator syncytium virus (RSV) infection. SOLUTION: Benzodiazepine derivative of formula (I), and pharmaceutically acceptable salts thereof, are found to be active against RSV. In the formula: R1represents aryl, heteroaryl or the like; R2represents hydrogen or the like; each R3is the same or different and represents various substituents; n is from 0 to 3; R4represents hydrogen or the like; R5represents aryl, heteroaryl, carbocyclyl, heterocyclyl, aryl-(1-6C alkyl)-, heteroaryl-(1-6C alkyl)-, carbocyclyl-(1-6C alkyl)-, heterocyclyl-(1-6C alkyl)-, aryl-C(O)-C(O)-, heteroaryl-C(O)-C(O)-, carbocyclyl-C(O)-C(O)-, heterocyclyl-C(O)-C(O)- or, -XR6or the like. COPYRIGHT: (C)2011,JPO&INPIT