IMPLANTABLE POLYMERIC DEVICE FOR SUSTAINED RELEASE OF DOPAMINE AGONIST

PROBLEM TO BE SOLVED: To provide an improved dosing means which enables continuous dosing of a dopamine agonist for a long period. SOLUTION: The implantable device for dosing a dopamine agonist to a mammal requiring dosing of the dopamine agonist includes the dopamine agonist and a biocompatible non...

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Hauptverfasser:	KLEPPNER SOFIE, PATEL RAJESH A, BUCALO LOUIS R, COSTANTINI LAUREN
Format:	Patent
Sprache:	eng
Schlagworte:	CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, ORSURGICAL ARTICLES DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROMTHE BODY DISINFECTION, STERILISATION, OR DEODORISATION OF AIR HUMAN NECESSITIES HYGIENE MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICALARTICLES MEDICAL OR VETERINARY SCIENCE METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS INGENERAL PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	PROBLEM TO BE SOLVED: To provide an improved dosing means which enables continuous dosing of a dopamine agonist for a long period. SOLUTION: The implantable device for dosing a dopamine agonist to a mammal requiring dosing of the dopamine agonist includes the dopamine agonist and a biocompatible nonerodible polymeric matrix. Here, when the dopamine agonist is sealed in the matrix and the implantable device is subcutaneously implanted in a mammal, the dopamine agonist implantable device releases dopamine agonist continuously in vivo through pores that open to the surface of the matrix at a rate that results in a plasma level of at least about 0.01 ng/mL in a stationary state. COPYRIGHT: (C)2011,JPO&INPIT