RECOMBINANT MICROORGANISM, METHOD FOR SCREENING Tat SECRETION SYSTEM INHIBITOR, AND KIT FOR SCREENING Tat SECRETION SYSTEM INHIBITOR

PROBLEM TO BE SOLVED: To screen a substance targeting the Tat secretion system, i.e. having activities for inhibiting the Tat secretion system from various test substances. SOLUTION: A fused gene obtained by fusing a gene encoding a matured region in a subunit constituting a drug excretion pump, wit...

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Hauptverfasser:	AKIBA TAKANARI, HASEGAWA FUMIHIKO, YONEYAMA YUTAKA, ANDO TASUKE, ABE TAKAYOSHI
Format:	Patent
Sprache:	eng
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS OR TEST PAPERS THEREFOR COMPOSITIONS THEREOF CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES CULTURE MEDIA ENZYMOLOGY INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PHYSICS PROCESSES OF PREPARING SUCH COMPOSITIONS PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS TESTING VINEGAR WINE
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Zusammenfassung:	PROBLEM TO BE SOLVED: To screen a substance targeting the Tat secretion system, i.e. having activities for inhibiting the Tat secretion system from various test substances. SOLUTION: A fused gene obtained by fusing a gene encoding a matured region in a subunit constituting a drug excretion pump, with a gene encoding a region containing a signal sequence of a protein secreted through the Tat secretion system in a microorganism having the Tat (Twin Arginine Translocation) secretion system is expressed, and the drug excretion pump is formed by allowing the subunit to be translocated through the Tat secretion system. COPYRIGHT: (C)2011,JPO&INPIT