METHOD OF DETECTING DEGREE OF ADVERSE INFLUENCE OF MACROPHAGE ON ANIMAL

PROBLEM TO BE SOLVED: To find a marker which directly reflects negative effects of a macrophage on a patient. SOLUTION: The present invention provides a method for determining the degree of macrophage-associated negative effects on a vertebrate including a human and includes assaying diacetylpolyamine contained in a sample. According to the method, metabolic conditions of macrophages can be monitored, and the degree of macrophage-associated negative effects on a vertebrate including humans can be determined. More specifically, the present invention can predict, through assay of diacetylpolyamine, pathological condition which is considered a macrophage-related disease; e.g., recurrence of cancer or malignant tumor, or infiltration or activation of cancer or malignant tumor cells; denaturation or degeneration of neurons associated with Alzheimer's disease; or the onset or progression of an autoimmune disease (e.g., rheumatism or Crohn's disease) or arteriosclerosis, and thereby is very useful for clinical tests. COPYRIGHT: (C)2011,JPO&INPIT